In this paper, an efficient hybrid genetic algorithm (HGA) and its variants for the well-known combinatorial optimization problem, the quadratic assignment problem (QAP) are discussed. In particular, we tested our algorithms on a special type of QAPs, the structured quadratic assignment problems. The results from the computational experiments on this class of problems demonstrate that HGAs allow to achieve near-optimal and (pseudo-)optimal solutions at very reasonable computation times. The obtained results also confirm that the hybrid genetic algorithms are among the most suitable heuristic approaches for this type of QAPs.